HCID 21968280, Verbindung → HCID 21968279, Verbindung

HRID 1106508Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1106508
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C@@H:7]3[CH2:12][CH2:13][N:14](CC4C=CC=CC=4)[CH2:15][C@H:6]3[C:5]=2[CH:4]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C@@H:7]3[CH2:12][CH2:13][NH:14][CH2:15][C@H:6]3[C:5]=2[CH:4]=1

Komponenten

5

Edukt 2

HCID 21968280HCID 21968280, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 21968279HCID 21968279, VerbindungAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of intermediate 8 (11.3 g) in methanol (250 ml) was hydrogenated with palladium-on-carbon (10%, 2 g) as a catalyst. After uptake of hydrogen (1 equivalent), the catalyst was filtered off and the filtrate was evaporated. The residue was solidified in DIPE (30 ml). The precipitate was filtered off and dried, yielding 6.1 g (78%) of (±)-trans-2,3,4,4a,5,9b-hexahydro-8-methoxy-1H-pyrido[4,3-b]indole (intermediate 10).

Aufarbeitung

  1. customthe filtrate was evaporated
  2. filtrationThe precipitate was filtered off
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-101d16f8f0d4451f89cd84ce1543db2d
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06057325

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