N(OC(C)(C)C)=O.[CH3:8][C:9]1[C:10]([N+:20]([O-:22])=[O:21])=[C:11](N)[C:12]([CH3:18])=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16]>CN(C)C=O>[CH3:8][C:9]1[C:10]([N+:20]([O-:22])=[O:21])=[CH:11][C:12]([CH3:18])=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16]To a solution of t-butyl nitrite (t-BuONO) (7.32 g) in dimethyl formamide (DMF) (50 mL, from Mallinckrodt) at 65° C. was added dropwise a solution of 3,6-dimethyl-2,4-dinitro-phenylamine (10 g, from above) in DMF (50 mL) during 5-10 min. The mixture was heated at 65° C. for 15 min and the solvent was removed under reduced pressure. The residue was partitioned between dichloromethane (300 mL) and half-saturated sodium chloride solution. The dichloromethane solution was washed with additional half-saturated sodium chloride solution (300 mL) and dried over magnesium sulfate. After evaporation of the solvent, the residue was taken up in dichloromethane (250 mL) and passed through a short column (silica gel). Eluting with dichloromethane gave 2,5-dimethyl-1,3-dinitro-benzene (7.75 g).
Wird geladen…
