Formamide → Ethyl 4-methyloxazole-5-carboxylate

HRID 1107695

Reaktionsgleichung

Reaktionsgleichung von HRID 1107695
[CH2:1]([O:3][C:4](=[O:10])[CH:5](Cl)[C:6]([CH3:8])=O)[CH3:2].[CH:11]([NH2:13])=[O:12].C(=O)([O-])[O-].[K+].[K+]>>[CH2:1]([O:3][C:4]([C:5]1[O:12][CH:11]=[N:13][C:6]=1[CH3:8])=[O:10])[CH3:2]

Komponenten

4

Edukt 3

HCID 713FormamideHCID 11430Potassium CarbonateHCID 11858Ethyl 2-chloroacetoacetate

Produkt 1

HCID 88558Ethyl 4-methyloxazole-5-carboxylateAusbeute 39,8 %

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To ethyl-2-chloroacetoacetate(5.6 g) was added formamide(4.6 g). The reaction mixture was stirred at 120° C. for 12 hours, cooled to 0° C. and aqueous potassium carbonate was added thereto. The mixture was extracted with benzene, dried with anhydrous magnesium sulfate, and concentrated in vacuo to obtain the target product(2.1 g).

Aufarbeitung

  1. temperaturecooled to 0° C.
  2. extractionThe mixture was extracted with benzene
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5df6a61042a447b080cb08964bf943f0
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06063778

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