Sodium Carbonate → Spiro[indene-1,4'-piperidine]

HRID 1110044Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1110044
Cl.[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[Na+].[Na+]>O>[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 10340Sodium CarbonateHCID 22509344Spiro[indene-1,4'-piperidine] hydrochloride

Produkt 1

HCID 10330052Spiro[indene-1,4'-piperidine]

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Spiro[1H-indene-1,4'-piperidine]hydrochloride (400 mg, 1.8 mmol), prepared according to Example 1, step 3, was dissolved in water (10 ml), and the solution made alkaline with sodium carbonate. The mixture was extracted with dichloromethane (3×10 ml), the organic layers separated, dried (MgSO4) and evaporated in vacuo. The free base was used without any further purification.

Aufarbeitung

  1. extractionThe mixture was extracted with dichloromethane (3×10 ml)
  2. customthe organic layers separated
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo
  5. customThe free base was used without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-200b2f52d402459d8bef0f27cc92a81d
Quelldatensatz
uspto-grants-1994_06
Patentnummer
US05324733

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