Hydrochloric Acid → HCID 178516554, Verbindung

HRID 1110884

Reaktionsgleichung

Reaktionsgleichung von HRID 1110884
C[C:2](C)([O-:4])C.[K+].[C:7]1([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][C:14]2=[O:22])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(OCC)=O.Cl>O.C(O)C>[C:7]1([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[CH:2][OH:4])[C:14]2=[O:22])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 3147871-PhenyloxindoleHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 178516554HCID 178516554, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Potassium t-butoxide (1.63 g, 14.5 mmoles) and 5 ml absolute ethanol were heated to 80°. 1-Phenyl-2(1H,3H)-indolone (2.09 g, 10 mmoles) was added, followed by ethyl formate (1.09 ml, 13.5 mmoles). The mixture was heated 5 minutes, cooled to 25°, and the nearly solid mass diluted with 50 ml H2O and crushed ice, acidified to pH 3 with 3N HCl and title product recovered by filtration, 2.2 g, m.p. 192°-195°; m/e 237. cf J. Prakt. Chem. 135:345-360 (1932); J. Med. Chem. 8:637 (1965).

Aufarbeitung

  1. temperatureThe mixture was heated 5 minutes
  2. temperaturecooled to 25°
  3. customcrushed ice

Quellen und Nachweise

ORD-Eintrag
ord-e65dbd6882c144b091e44b076a1129b8
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04977178

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