Benzene → 3-Chlorobenzophenone

HRID 1112036

Reaktionsgleichung

Reaktionsgleichung von HRID 1112036
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[CH:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[Cl-].[Al+3].[Cl-].[Cl-]>CCOCC>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:6]

Komponenten

5

Edukt 3

HCID 241BenzeneHCID 69252Benzoyl chloride, 3-chloro-HCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 660983-Chlorobenzophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a refluxing solution containing 43.9g (0.25 mole) of 3-chlorobenzoyl chloride in 120 ml. of dry benzene is added 30.0 g. (0.225 mole) of anhydrous aluminum chloride in several portions over a period of 10 minutes. When the reaction is complete, as indicated by vapor phase chromatographic (vpc) techniques, the mixture is cooled to 25° and diluted with ether. Extraction with dilute base is followed by thorough drying (magnesium sulfate) and concentration in vacuo. Final purification is effected by recrystallization from ether-hexane to afford 13.7g (0.06 mole) of 3-chlorobenzophenone, m.p. 84°-85°.

Aufarbeitung

  1. temperaturethe mixture is cooled to 25°
  2. extractionExtraction
  3. additionwith dilute base
  4. customby thorough drying
  5. concentration(magnesium sulfate) and concentration in vacuo
  6. customFinal purification
  7. customis effected by recrystallization from ether-hexane

Quellen und Nachweise

ORD-Eintrag
ord-39f1c9054f564be2ac5a40206194359b
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04120687

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