UP 614-04 → 2-(1-Phenyl-2,3-dihydro-imidazo-(4,5-b)pyridin-2-on-3-yl-methyl)-morpholine maleate

HRID 1112350

Reaktionsgleichung

Reaktionsgleichung von HRID 1112350
Cl.C([N:9]1[CH2:14][CH2:13][O:12][CH:11]([CH2:15][N:16]2[C:20]3=[N:21][CH:22]=[CH:23][CH:24]=[C:19]3[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]2=[O:31])[CH2:10]1)C1C=CC=CC=1.Cl.CN1C2C=CC=CC=2N(CC2OCCNC2)C1=O.[C:51]([OH:58])(=[O:57])/[CH:52]=[CH:53]\[C:54]([OH:56])=[O:55]>C(O)(C)C>[C:51]([OH:58])(=[O:57])/[CH:52]=[CH:53]\[C:54]([OH:56])=[O:55].[C:25]1([N:18]2[C:19]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[N:16]([CH2:15][CH:11]3[O:12][CH2:13][CH2:14][NH:9][CH2:10]3)[C:17]2=[O:31])[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Komponenten

5

Edukt 3

HCID 134375UP 614-04HCID 444266Maleic AcidHCID 706017304-Benzyl-2-(1-phenyl-2,3-dihydro-imidazo(4,5-b)pyridin-2-on-3-yl-methyl)-morpholine hydrochloride

Produkt 1

HCID 867360792-(1-Phenyl-2,3-dihydro-imidazo-(4,5-b)pyridin-2-on-3-yl-methyl)-morpholine maleate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel2×

Versuchsvorschrift

19 g of 4-benzyl-2-(1-phenyl-2,3-dihydro-imidazo-(4,5-b)pyridin-2-on-3yl-methyl)-morpholine hydrochloride are treated in accordance with part (a) of Example 2. The oil obtained is dissolved in hot isopropanol. A hot solution of maleic acid in isopropanol is added. The salt precipitates slowly. Recrystallization from isopropanol gives 5 g of 2-(1-phenyl-2,3-dihydro-imidazo-(4,5-b)pyridin-2-on-3-yl-methyl)-morpholine maleate, m.p. 190° C.

Aufarbeitung

  1. customThe oil obtained
  2. customThe salt precipitates slowly
  3. customRecrystallization from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-246bfad5f0804e13a0b57b1bc9653651
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04122175

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