Water → Apovincamine furoate

HRID 1112365

Reaktionsgleichung

[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[OH2:26]>>[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[O:26]1[CH:2]=[CH:3][CH:19]=[C:18]1[C:20]([O-:22])=[O:21]

Komponenten

Edukt 2

HCID 962Water

HCID 71204Apovincamine

Produkt 1

HCID 86736088Apovincamine furoate

Versuchsvorschrift

By repeating the preceding example, there are obtained 8.2 g of the salt from 6.73 g (2.10-2 moles) of apovincamine and 2.24 g (2.10-2 moles) of furan-2-carboxylic acid. The product has a melting point of about 120° C. is insoluble in water and soluble in alcohol; the apovincamine content thereof is 66%.

Quellen und Nachweise

ORD-Eintrag: ord-8c3f92ad959546a08b49c4140fbb0cbd
Quelldatensatz: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04122179

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