Water → 2-(N-[3-chlorobenzyl]isobutyramido)-4-methyloxazole

HRID 1112391

Reaktionsgleichung

Reaktionsgleichung von HRID 1112391
[C:1]([NH:6][C:7]1[O:8][CH:9]=[C:10]([CH3:12])[N:11]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+].[Cl:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23]Br.O>CN(C)C=O>[Cl:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23][N:6]([C:7]1[O:8][CH:9]=[C:10]([CH3:12])[N:11]=1)[C:1](=[O:5])[CH:2]([CH3:4])[CH3:3]

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 233485622-iso Butyramido-4-methyloxazole

Produkt 1

HCID 213236682-(N-[3-chlorobenzyl]isobutyramido)-4-methyloxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

2-iso Butyramido-4-methyloxazole (11.1 g., 0.066 mol) prepared in a manner similar to that described in Example 20, was dissolved in dry dimethylformamide. Solid potassium carbonate (10.47 g., 0.076 mol) and 3-chlorobenzyl bromide (15.6 g., 0.076 mol) were added and the stirred mixture was heated at 70° C for 2 hours, cooled and poured into cold water. The solution was extracted with ether and the extract was dried over magnesium sulphate and evaporated. The residue b.p. distilled to give the product, 12.3 g., b.p, 115°-120° C/0.08 mm.

Aufarbeitung

  1. temperaturecooled
  2. extractionThe solution was extracted with ether
  3. dry with materialthe extract was dried over magnesium sulphate
  4. customevaporated
  5. distillationdistilled
  6. customto give the product, 12.3 g
  7. customb.p, 115°-120° C/0.08 mm

Quellen und Nachweise

ORD-Eintrag
ord-8ad118046858491d837391890248cf80
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04122183

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