2-Aminopyridine → HCID 178515422, Verbindung

HRID 1112522Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1112522
[Cl-].[Al+3].[Cl-].[Cl-].[N-:5]=[N+:6]=[N-:7].[Na+].[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1.C([O:18][CH:19]=[C:20]([C:26]#[N:27])[C:21](OCC)=O)C>O1CCCC1>[NH:5]1[C:26]([C:20]2[C:19](=[O:18])[N:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]3=[N:9][CH:21]=2)=[N:27][N:7]=[N:6]1

Komponenten

6

Edukt 4

HCID 104392-AminopyridineHCID 33557Sodium AzideHCID 789432-Propenoic acid, 2-cyano-3-ethoxy-, ethyl esterHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 178515422HCID 178515422, VerbindungAusbeute 15,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Aluminum chloride (1.73 g., 12.96 mmoles) was added to tetrahydrofuran (45 ml.) at -20°. Sodium azide (2.52 g., 38.71 mmoles) was then added and the mixture heated under reflux for 40 minutes. To this mixture was added 2-aminopyridine (1.0 g., 10.62 mmoles) and ethyl ethoxymethylenecyanoacetate (1.8 g., 10.62 mmoles). The mixture was heated under reflux for 18 hours. The mixture was concentrated and the residue treated with water (50 ml.). The mixture was acidified to pH 3 with 6N hydrochloric acid. The solid material was collected and suspended in 3% aqueous sodium bicarbonate. The mixture was heated under reflux for 5 minutes, filtered, and the filtrate acidified to pH 4 with 6N hydrochloric acid. The precipitate was recrystallized from N,N-dimethylformamide to give the title compound (0.35 g., 15.4%), m.p. 312°-313° (decomp).

Aufarbeitung

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 40 minutes
  3. temperatureThe mixture was heated
  4. temperatureunder reflux for 18 hours
  5. concentrationThe mixture was concentrated
  6. additionthe residue treated with water (50 ml.)
  7. customThe solid material was collected
  8. temperatureThe mixture was heated
  9. temperatureunder reflux for 5 minutes
  10. filtrationfiltered
  11. customThe precipitate was recrystallized from N,N-dimethylformamide

Quellen und Nachweise

ORD-Eintrag
ord-6cfd725b15ab41829db020e49e195d80
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04122274

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