N,O-Dimethylhydroxylamine → N'-{4-[(2-Fluorophenyl)methoxy]phenyl}-N-methoxy-N-methylurea

HRID 1112570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1112570
[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]=[C:13]=[O:14])=[CH:8][CH:7]=1.[CH3:19][NH:20][O:21][CH3:22]>C1C=CC=CC=1>[F:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([NH:12][C:13]([N:20]([CH3:19])[O:21][CH3:22])=[O:14])=[CH:10][CH:11]=1

Komponenten

4

Edukt 2

HCID 14232N,O-DimethylhydroxylamineHCID 22762251HCID 22762251, Verbindung

Produkt 1

HCID 12893493N'-{4-[(2-Fluorophenyl)methoxy]phenyl}-N-methoxy-N-methylureaAusbeute 59,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel2×

Versuchsvorschrift

To a solution of 4-(2-fluorobenzyloxy)phenyl isocyanate (24.3 g) in benzene (150 ml), a solution of N,O-dimethylhydroxylamine (20 g) in benzene (100 ml) is added dropwise at 20° to 30° C., and the resulting mixture is stirred at the same temperature for 30 minutes. The reaction mixture is concentrated in vacuo, and the residual crude crystals are recrystallized from ethanol to give N-[4-(2-fluorobenzyloxy)phenyl]-N'-methyl-N'-methoxyurea (Compound No. 1) (18 g) as white scales. M.P., 99° to 100° C.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe residual crude crystals are recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-3cb20502903140ee8aefd57c2f780501
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04123256

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