Hydrochloric Acid → trans-Aconitic acid

HRID 1112608

Reaktionsgleichung

Reaktionsgleichung von HRID 1112608
[OH-].[Ca+2].[OH-].Cl.[C:5]([OH:17])(=[O:16])[CH:6]([CH:8]([CH2:12][C:13]([OH:15])=[O:14])[C:9]([OH:11])=[O:10])O>O>[CH2:12]([C:13]([OH:15])=[O:14])/[C:8](/[C:9]([OH:11])=[O:10])=[CH:6]\[C:5]([OH:17])=[O:16]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 1198Isocitric AcidHCID 6093208Calcium Hydroxide2×

Produkt 1

HCID 444212trans-Aconitic acidAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

Thirty one grams (0.1 mole) of product prepared as in Example I-B is mixed with 200 mls water. Thirty grams (0.4 mole) calcium hydroxide is added slowly while the pH of the reaction medium is maintained at 10-10.5 and the temperature is kept between 70° and 75° C. After the addition of calcium hydroxide is complete, the reaction mixture is stirred at 75° C. for an additional two hours and then cooled. 90 grams of a 20% by weight hydrochloric acid solution is added slowly to a pH of 1.3 and the resulting solution is then filtered. The filtrate is evaporated to dryness in vacuo and the residue extracted with acetone. The acetone extract is filtered and 19.5 grams of product consisting of 53.5% (60% yield) transaconitic acid and 5.8% of a mixture of lactones of isocitric acid and alloisocitric acid.

Aufarbeitung

  1. temperatureis maintained at 10-10.5
  2. customis kept between 70° and 75° C
  3. temperaturecooled
  4. filtrationthe resulting solution is then filtered
  5. customThe filtrate is evaporated to dryness in vacuo
  6. extractionthe residue extracted with acetone
  7. extractionThe acetone extract
  8. filtrationis filtered

Quellen und Nachweise

ORD-Eintrag
ord-e6bcbd2ae41c499eb49e303d3f558a72
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04123459

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