Benzyl Bromide → 1-Bromo-4-phenylmethoxybenzene

HRID 11201

Reaktionsgleichung

Reaktionsgleichung von HRID 11201
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CC(C)=O.C(OCC)(=O)C.O>[CH2:15]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Komponenten

7

Edukt 3

HCID 7498Benzyl BromideHCID 78084-BromophenolHCID 11430Potassium Carbonate

Produkt 1

HCID 1388351-Bromo-4-phenylmethoxybenzene

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5–6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

Aufarbeitung

  1. temperatureThe reaction was refluxed under nitrogen
  2. temperatureAfter 5–6 hours of reflux
  3. customthe organic layer was separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated to dryness
  6. customto afford a white fluffy powder

Quellen und Nachweise

ORD-Eintrag
ord-9c38a67482a74a60b22a9dd04f69b8a7
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07097995B2

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