N,N,2,2-Tetramethylpropane-1,3-diamine → Akt-l-1

HRID 11227

Reaktionsgleichung

Reaktionsgleichung von HRID 11227
Cl[C:2]1[C:3]([CH:17]2[CH2:20][CH2:19][CH2:18]2)=[CH:4][C:5]2[N:6]([C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:9][N:10]=2)[N:7]=1.[CH3:21][N:22]([CH3:29])[CH2:23][C:24]([CH3:28])([CH3:27])[CH2:25][NH2:26]>O>[CH:17]1([C:3]2[C:2]([NH:26][CH2:25][C:24]([CH3:28])([CH3:27])[CH2:23][N:22]([CH3:29])[CH3:21])=[N:7][N:6]3[C:8]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:9][N:10]=[C:5]3[CH:4]=2)[CH2:20][CH2:19][CH2:18]1

Komponenten

4

Edukt 2

HCID 104477N,N,2,2-Tetramethylpropane-1,3-diamineHCID 110005936-Chloro-7-cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazine

Produkt 1

HCID 10271028Akt-l-1

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

6-Chloro-7-cyclobutyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine (100 mg) and N,N,2,2-tetramethyl-1,3-propanediamine (2 ml) were heated together in a sealed tube at 70° C. for 16 hours. Cooled and water (5 ml) added. Precipitate filtered, washed (water, ether) and dried. 1H NMR (250 MHz, DMSO) δ 1.20 (6H, s), 2.10 (1H, m), 2.24–2.65 (14H, m), 3.53–3.70 (2H, m), 7.69–7.82 (4H, m), 8.03 (1H,s), 8.70 (2H, m). MS (ES+) MH+=379

Aufarbeitung

  1. temperatureCooled
  2. filtrationPrecipitate filtered
  3. washwashed (water, ether)
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9fa064f3e1f3429d9c2af7fa8d1def04
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098208B2

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