5-Benzyloxy-2-ethoxybenzonitrile → 2-Ethoxy-5-hydroxybenzonitrile

HRID 11262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 11262
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:17][CH2:18][CH3:19])=[C:13]([CH:16]=1)[C:14]#[N:15])C1C=CC=CC=1>CO.[Pd]>[CH2:18]([O:17][C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:16][C:13]=1[C:14]#[N:15])[CH3:19]

Komponenten

4

Edukt 1

HCID 219731695-Benzyloxy-2-ethoxybenzonitrile

Produkt 1

HCID 219731772-Ethoxy-5-hydroxybenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

40.02 g of 5-benzyloxy-2-ethoxybenizonitrile (158 mmol) (example 32A) and 5% Pd/C (4.0 g) are initially charged in 1 l of methanol. The mixture is then hydrogenated under an atmosphere of hydrogen (1 atm) for about 4 h. The mixture is filtered through kieselguhr and evaporated and the crystalline residue is dried under reduced pressure.

Aufarbeitung

  1. filtrationThe mixture is filtered through kieselguhr
  2. customevaporated
  3. customthe crystalline residue is dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-508ee62d64134b1dba54107904fed0f8
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098207B2

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