5-Nitro-2-propoxyphenyl-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one → 2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

HRID 11267

Reaktionsgleichung

Reaktionsgleichung von HRID 11267
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:26][CH2:27][CH2:28][CH3:29])=[C:8]([C:10]2[NH:15][C:14](=[O:16])[C:13]3=[C:17]([CH3:25])[N:18]=[C:19]([CH:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)[N:12]3[N:11]=2)[CH:9]=1)([O-])=O>O1CCCC1.C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:26][CH2:27][CH2:28][CH3:29])=[C:8]([C:10]2[NH:15][C:14](=[O:16])[C:13]3=[C:17]([CH3:25])[N:18]=[C:19]([CH:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)[N:12]3[N:11]=2)[CH:9]=1

Komponenten

4

Edukt 1

HCID 1356049635-Nitro-2-propoxyphenyl-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

Produkt 1

HCID 1356049252-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 21873804Tetrahydrofuran ethanolLösungsmittel

Versuchsvorschrift

Analogously to the procedure of example 42A, 5.13 g (12.96 mmol) of the compound from example 43A are hydrogenated in tetrahydrofuran/ethanol (1:1) using 1.11 g of 10% Pd/C. The product is purified by silica gel chromalography using toluene and ethyl acetate as solvent gradient.

Aufarbeitung

  1. customThe product is purified by silica gel chromalography

Quellen und Nachweise

ORD-Eintrag
ord-4282992d9f884e20a0f83bdc2c8a2c5d
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098207B2

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