Iodine → Methyl 4-amino-3-iodobenzoate

HRID 11415

Reaktionsgleichung

Reaktionsgleichung von HRID 11415
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.[I:12]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+2]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][C:11]=1[I:12]

Komponenten

5

Edukt 2

HCID 807IodineHCID 12082Methyl 4-aminobenzoate

Produkt 1

HCID 4104649Methyl 4-amino-3-iodobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418844HCID 178418844, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Methyl 4-aminobenzoate (30.23 g, 200 mmol) was added to a mixture of iodine (60.91 g, 240 mmol) and silver sulfate (81.07 g, 260 mmol) in 1 L of ethanol at room temperature. The mixture was stirred at room temperature for 18 hours, filtered over Celite and the filtrate was evaporated to dryness under reduced pressure. The residue was chromatographed on silica gel (230–400 mesh) and eluted with 1% ethyl acetate in hexane to give 35 g (63%).

Aufarbeitung

  1. filtrationfiltered over Celite
  2. customthe filtrate was evaporated to dryness under reduced pressure
  3. customThe residue was chromatographed on silica gel (230–400 mesh)
  4. washeluted with 1% ethyl acetate in hexane
  5. customto give 35 g (63%)

Quellen und Nachweise

ORD-Eintrag
ord-f7ee27120d3e45df9a00b6188ab0a4c8
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098231B2

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