3-(4-Fluorophenyl)-2,1-benzisoxazole → 2-Amino-4'-fluorobenzophenone

HRID 1148

Reaktionsgleichung

Reaktionsgleichung von HRID 1148
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][N:10]=[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)=[CH:4][CH:3]=1>O1CCCC1.C(N(CC)CC)C.[Pd]>[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)=[O:9]

Komponenten

5

Edukt 1

HCID 196948213-(4-Fluorophenyl)-2,1-benzisoxazole

Produkt 1

HCID 98372872-Amino-4'-fluorobenzophenone

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To a suspension of (16) (42.6 g, 0.2 mol) in 750 ml of dry tetrahydrofuran (THF) and 20 ml of triethylamine is added 5% palladium on charcoal (6 g). The vigorously stirred suspension is flushed with hydrogen gas and stirred at room temperature under a hydrogen atmosphere until absorption of hydrogen ceases (approximately 90-90% of the molar amount; 8-10 hours). The catalyst is removed by filtration through a bed of celite, and the solvent is removed under reduced pressure. The product (16) is recrystallized from toluene.

Aufarbeitung

  1. customThe vigorously stirred suspension is flushed with hydrogen gas
  2. custom8-10 hours
  3. customThe catalyst is removed by filtration through a bed of celite
  4. customthe solvent is removed under reduced pressure
  5. customThe product (16) is recrystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-92bc8cb4ed55424491eb833aaed1c16a
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723573

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