Phenyl Isothiocyanate → HCID 4244266, Verbindung

HRID 1153968Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1153968
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:10][C:11]1[CH:23]=[CH:22][C:14]([CH2:15][NH:16][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[F:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:15][N:16]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[S:9])=[CH:22][CH:23]=1

Komponenten

4

Edukt 2

HCID 7673Phenyl IsothiocyanateHCID 834084HCID 834084, Verbindung

Produkt 1

HCID 4244266HCID 4244266, VerbindungAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

6.75 g (0.05 mol) of phenyl isothiocyanate were rapidly added dropwise to a solution of 9.65 g (0.05 mol) of N-4-fluorobenzyl-N-cyclopentylamine in 80 ml of toluene. The mixture was heated to the boil for 30 minutes, the solvent was distilled off in vacuo, and the residue was recrystallized from isopropanol. 13.8 g of N-4-fluorobenzyl-N-cyclopentyl-N'-phenylthiourea of melting point 135° C. were obtained.

Aufarbeitung

  1. temperatureThe mixture was heated to the boil for 30 minutes
  2. distillationthe solvent was distilled off in vacuo
  3. customthe residue was recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-0996041c7caf44249cfbd958caacc99b
Quelldatensatz
uspto-grants-1984_12
Patentnummer
US04487783

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