Hydrazine hydrate (1:1) → N-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]hydrazinecarbothioamide

HRID 1154730Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1154730
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)=[C:2]=[S:3].O.[NH2:25][NH2:26]>O1CCOCC1>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:7]3[CH:8]=[CH:9][C:4]([NH:1][C:2]([NH:25][NH2:26])=[S:3])=[CH:5][CH:6]=3)[CH2:11][CH2:12]2)=[CH:17][CH:18]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 155818991-(4-Isothiocyanatophenyl)-4-(4-methoxyphenyl)piperazine

Produkt 1

HCID 13368247N-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]hydrazinecarbothioamideAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 47.8 parts of 1-(4-isothiocyanatophenyl)-4-(4-methoxyphenyl)piperazine, 100 parts of hydrazine hydrate and 400 parts of 1,4-dioxane is stirred and refluxed for 1 hour. The reaction mixture is cooled and poured onto water. The precipitated product is filtered off, washed with water and with methanol and dried, yielding 46 parts (89%) of N-{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}hydrazinecarbothioamide.

Aufarbeitung

  1. temperaturerefluxed for 1 hour
  2. temperatureThe reaction mixture is cooled
  3. additionpoured onto water
  4. filtrationThe precipitated product is filtered off
  5. washwashed with water and with methanol
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b8469417d0cc4bf08a0be3c25c1c13b0
Quelldatensatz
uspto-grants-1984_12
Patentnummer
US04490530

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