Methane → HCID 12900686, Verbindung

HRID 1155694Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1155694
[ClH:1].[NH:2]1[C:10]2[C:5](=[C:6]([C:11]3([OH:24])[CH2:16][CH2:15][CH2:14][N:13](CC4C=CC=CC=4)[CH2:12]3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.C>CO>[ClH:1].[NH:2]1[C:10]2[C:5](=[C:6]([C:11]3([OH:24])[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

Komponenten

4

Edukt 2

HCID 297MethaneHCID 12900684HCID 12900684, Verbindung

Produkt 1

HCID 12900686HCID 12900686, VerbindungAusbeute 96,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

12.7 g of the hydrochloride of Step C in 500 ml of methanol were hydrogenated at 60° C. in the presence of 3.6 g of palladized active charcoal and the mixture was filtered. The filtrate was concentrated to dryness to obtain 9 g of 3-(1H-indol-4-yl)-3-piperidinol hydrochloride which was used as is for the next step.

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. concentrationThe filtrate was concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-8678530feb0d4bcfb27a6ba5ae904f0a
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04332808

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