2-(4-Chlorophenoxy)-5-nitropyridine → 6-(4-Chlorophenoxy)pyridin-3-amine

HRID 1156210Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1156210
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]=2)=[CH:4][CH:3]=1.[H][H]>O1CCCC1.C(OCC)(=O)C.[Pt](=O)=O>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][N:8]=2)=[CH:4][CH:3]=1

Komponenten

6

Edukt 2

HCID 2771852-(4-Chlorophenoxy)-5-nitropyridineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 4206446-(4-Chlorophenoxy)pyridin-3-amineAusbeute 94,2 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 345198Adams' catalystKatalysatorHCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4-Chlorophenoxy-5-nitropyridine (19.9 g) and platinum dioxide (0.1 g) were suspended in a mixture of tetrahydrofuran (100 ml) and ethyl acetate (50 ml), and catalytic reduction was carried out until 5.0 liters of hydrogen were absorbed. After removal of the catalyst by filtration, the solvent was distilled out under reduced pressure. The precipitated crystals were washed with a small amount of ether to give 16.5 g of 4-chlorophenoxy-5-aminopyridine as white crystals. M.P., 87°-88° C.

Aufarbeitung

  1. customwere absorbed
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. distillationthe solvent was distilled out under reduced pressure
  5. washThe precipitated crystals were washed with a small amount of ether

Quellen und Nachweise

ORD-Eintrag
ord-17fe63a8741e42b2941a15393552ca86
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04334912

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