HCID 20535629, Verbindung → CHROMONE2CARBOXYLICACID52HYDROXYPROPOXY8PROPYL

HRID 1156225Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1156225
O1CCCCC1[O:7][CH:8]([CH3:28])[CH2:9][O:10][C:11]1[C:16]2[C:17](=[O:24])[CH:18]=[C:19]([C:21]([OH:23])=[O:22])[O:20][C:15]=2[C:14]([CH2:25][CH2:26][CH3:27])=[CH:13][CH:12]=1>C(O)C.O.Cl>[OH:7][CH:8]([CH3:28])[CH2:9][O:10][C:11]1[C:16]2[C:17](=[O:24])[CH:18]=[C:19]([C:21]([OH:23])=[O:22])[O:20][C:15]=2[C:14]([CH2:25][CH2:26][CH3:27])=[CH:13][CH:12]=1

Komponenten

5

Edukt 1

HCID 20535629HCID 20535629, Verbindung

Produkt 1

HCID 121899CHROMONE2CARBOXYLICACID52HYDROXYPROPOXY8PROPYL

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidKatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A suspension of 5-[2-(tetrahydropyran-2-yloxy)propoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid (0.12 g) in ethanol (3 ml), water (2 ml) and concentrated hydrochloric acid (1 drop) was stirred for 15 minutes at ambient temperature. The mixture was then extracted with chloroform (3×20 ml) and the chloroform extracts bulked, dried and evaporated in vacuo. The residue was crystallised from acetone giving 5-(2-hydroxypropoxy)-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid m.g. 134°-135° C.

Aufarbeitung

  1. extractionThe mixture was then extracted with chloroform (3×20 ml)
  2. customdried
  3. customevaporated in vacuo
  4. customThe residue was crystallised from acetone

Quellen und Nachweise

ORD-Eintrag
ord-b0ea262d5a494c7eae27cdfd0e2e25cd
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04335048

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