Water → HCID 135752, Verbindung

HRID 1156547Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1156547
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:15][C:16]([N:18]([CH3:20])[CH3:19])=O)[CH2:14][CH2:13][CH:12]=[CH:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:15][CH2:16][N:18]([CH3:20])[CH3:19])[CH2:14][CH2:13][CH2:12][CH:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 20459997HCID 20459997, VerbindungHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 135752HCID 135752, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 1.0 g of 1-(m-methoxyphenyl)-N,N-dimethyl-3-cyclohexene-1-acetamide in 10 ml of absolute tetrahydrofuran is added to a suspension of 1 g of lithium aluminum hydride in 50 ml of absolute tetrahydrofuran, and the mixture is boiled at reflux overnight. After the addition of water, the separated precipitate is removed by filtration under suction and washed well with tetrahydrofuran, whereupon the filtrate is evaporated. The oil remaining behind is treated with 1 N hydrochloric acid. The neutral portion is taken up in ether. The acidic phase is made alkaline by the addition of concentrated ammonia and the liberated rac. 1-(m-methoxyphenyl)-N,N-dimethyl-2-cyclohexene-1-ethylamine is taken up in methylene chloride. The hydrochloride of this compound melts at 161°-162° C. (after recrystallization from ethyl acetate/ethanol).

Aufarbeitung

  1. temperatureat reflux overnight
  2. customthe separated precipitate is removed by filtration under suction
  3. washwashed well with tetrahydrofuran, whereupon the filtrate
  4. customis evaporated
  5. additionThe oil remaining behind is treated with 1 N hydrochloric acid
  6. additionby the addition of concentrated ammonia

Quellen und Nachweise

ORD-Eintrag
ord-9dc9c0d328324fb296ad55f138a7bdc2
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04336268

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