Water → 2-Chloro-4-phenylthiazole-5-carboxylic acid

HRID 1156604Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1156604
[Cl:1][C:2]1[S:3][C:4]([C:13]([O:15]CC)=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[OH-].[Na+].O>O1CCCC1>[Cl:1][C:2]1[S:3][C:4]([C:13]([OH:15])=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13041816Ethyl 2-chloro-4-phenyl-1,3-thiazole-5-carboxylate

Produkt 1

HCID 130418282-Chloro-4-phenylthiazole-5-carboxylic acidAusbeute 90,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 53.4 g (0.2 mole) of ethyl 2-chloro-4-phenyl-5-thiazolecarboxylate, 8.0 g (0.2 mole) of NaOH, 200 ml. of water and 400 ml. of tetrahydrofuran was stirred for 16 hours and extracted with ether. The organic layer was discarded. The aqueous layer was made acidic and the precipitate was collected and air-dried to give 43.2 g (90%) of the desired product, m.p. 170°-171° C.

Aufarbeitung

  1. extractionextracted with ether
  2. customthe precipitate was collected
  3. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-037f94191c814069bad2c02e159ffa2a
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04336389

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