Hydrochloric Acid → N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid

HRID 1156855Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1156855
[OH-].[Na+].C(O)C.[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[C:11]([NH:13][C:14]1[C:15](=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[C:16]([O:18]C)=[O:17])=[O:12].Cl>O>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:25]=[C:26]([O:30][CH3:31])[C:27]=1[O:28][CH3:29])[C:11]([NH:13][C:14]1[C:15](=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[C:16]([OH:18])=[O:17])=[O:12]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 12852881methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate

Produkt 1

HCID 12852880N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acidAusbeute 76,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 20 ml of a 10% aqueous solution of sodium hydroxide and 10 ml of ethanol is added 0.95 g of methyl N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilate and the mixture is stirred at room temperature for 1 hour. The reaction mixture is poured into 100 ml of water and after cooling, hydrochloric acid is added to make the mixture weakly acidic. The precipitated crystals are collected by filtration and recrystallized from ethanol to obtain 0.7 g of N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid as colorless needles.

Aufarbeitung

  1. temperatureafter cooling
  2. filtrationThe precipitated crystals are collected by filtration
  3. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ca415bc9bf2f4638b37f464c410206a9
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04337270

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