2-Amino-5-methoxy-4-methylbenzoic acid → 2-Amino-5-hydroxy-4-methylbenzoic acid

HRID 1157444Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1157444
[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([O:12]C)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>I>[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([OH:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

3

Edukt 1

HCID 212914972-Amino-5-methoxy-4-methylbenzoic acid

Produkt 1

HCID 588242352-Amino-5-hydroxy-4-methylbenzoic acidAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24841Hydrogen iodideLösungsmittel

Versuchsvorschrift

2-Amino-5-methoxy-4-methylbenzoic acid (2.7 g, 14.9 mmol, 61%) and aqueous hydriodic acid (40%, 80 mL) were heated at reflux for 36 h. The aqueous was evaporated under vacuum and the residue washed with ether to yield 2-amino-5-hydroxy-4-methylbenzoic acid (INTERMEDIATE V.1) (2.5 g, 14.9 mmol 100%)

Aufarbeitung

  1. temperatureat reflux for 36 h
  2. customThe aqueous was evaporated under vacuum
  3. washthe residue washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-7ca3f52abfb0491b85fd4405e7dcd31b
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07807686B2

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