N-methyl-2-pyrrolidone → HCID 178493790, Verbindung
Reaktionsgleichung
Cl.[CH3:2][O:3][C:4]1[CH:9]=[N:8][C:7]([O:10]C)=[C:6]2[NH:12][CH:13]=[CH:14][C:5]=12.CN1CCCC1=O>O>[OH:10][C:7]1[N:8]=[CH:9][C:4]([O:3][CH3:2])=[C:5]2[C:6]=1[NH:12][CH:13]=[CH:14]2Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 90 °C
Versuchsvorschrift
To 4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridine hydrochloride (50 g) taken in 2 L 3-necked round bottom flask, 250 ml N-methyl-2-pyrrolidinone was added followed by 8 ml of water, and was heated to 90° C. for about 4 hrs. The reaction mixture was cooled to room temperature, diluted with water (1 L) and the whole mixture was kept in cold room for about one hour. The resulting solid was collected by filtration, washed with cold water and dried in vacuum oven at 50° C. for 4 hrs to afford 7-hydroxyl-4-methoxy-6-azaindole as white solid.