2-(4-Fluoro-3-methyl-benzylidene)-hexanoic acid → 2-(4-Fluoro-3-methyl-benzyl)-hexanoic acid

HRID 1158123Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1158123
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]=[C:7]([CH2:11][CH2:12][CH2:13][CH3:14])[C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[CH3:17]>CO.[Pd]>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][CH:7]([CH2:11][CH2:12][CH2:13][CH3:14])[C:8]([OH:10])=[O:9])=[CH:4][C:3]=1[CH3:17]

Komponenten

4

Edukt 1

HCID 686422372-(4-Fluoro-3-methyl-benzylidene)-hexanoic acid

Produkt 1

HCID 595125992-(4-Fluoro-3-methyl-benzyl)-hexanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-(4-Fluoro-3-methyl-benzylidene)-hexanoic acid (0.850 g, 3.600 mmol) in 20 mL of MeOH, was added Pd—C (10 wt % on activated carbon, 0.170 g). After stirring at room temperature under H2 for 16 h, the reaction mixture was filtered through a pad of Celite and washed with MeOH. The filtrate was concentrated under reduced pressure and the crude product was used directly in the next step without further purification. LC-MS: tR=9.3 min; m/z 239 (M+H)+.

Aufarbeitung

  1. filtrationthe reaction mixture was filtered through a pad of Celite
  2. washwashed with MeOH
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customthe crude product was used directly in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-2676037a4820488b90fc49932f2725c2
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07807720B2

Notizen zur Reaktion

Wird geladen…