Hydrochloric Acid → 7-Tert-butyl-chroman-4-ol

HRID 1158784

Reaktionsgleichung

Reaktionsgleichung von HRID 1158784
[C:1]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][CH2:10][CH:11]1[O:16]CCCO1)([CH3:4])([CH3:3])[CH3:2].Cl>O1CCCC1.C(OCC)C>[C:1]([C:5]1[CH:6]=[C:7]2[C:17]([CH:11]([OH:16])[CH2:10][CH2:9][O:8]2)=[CH:18][CH:19]=1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 595485522-[2-(3-Tert-butyl-phenoxy)-ethyl]-[1,3]dioxane

Produkt 1

HCID 595485267-Tert-butyl-chroman-4-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The intermediate from step A was dissolved in 20 ml tetrahydrofuran. Concentrated hydrochloric acid (20 mL) was added, and the reaction mixture was stirred at ambient temperature for 4 hours, diluted with diethyl ether and washed with water. The isolated organic layer was dried with magnesium sulfate, filtered and the solvent removed under reduced pressure to give 2.87 g of crude 7-tert-butyl-chroman-4-ol which was used without further purification.

Aufarbeitung

  1. washwashed with water
  2. dry with materialThe isolated organic layer was dried with magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d25c8a5b32e84a68a77b3e7aee1f0cba
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07812019B2

Verknüpfte Notizen

Wird geladen…