Formamidine acetate → HCID 178435739, Verbindung

HRID 1159184

Reaktionsgleichung

Reaktionsgleichung von HRID 1159184
[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([CH2:13][CH:14]([NH2:17])[CH2:15][NH2:16])=[CH:10][CH:9]=[CH:8]2)[CH3:2].[C:18](O)(=O)C.C(N)=N>CCO>[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([CH2:13][CH:14]1[CH2:15][NH:16][CH:18]=[N:17]1)=[CH:10][CH:9]=[CH:8]2)[CH3:2]

Komponenten

4

Edukt 2

HCID 160693Formamidine acetateHCID 575431993-(8-Ethyl-naphthalen-1-yl)-propane-1,2-diamine

Produkt 1

HCID 178435739HCID 178435739, VerbindungAusbeute 60,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3-(8-ethyl-naphthalen-1-yl)-propane-1,2-diamine (60 mg) in EtOH (6 ml) was treated at r.t. under an argon atmosphere with formamidine acetate (30 mg). The reaction mixture was stirred at r.t. overnight, then concentrated. The crude product was purified by column chromatography (silica gel; eluent: CH2Cl2→CH2Cl2/MeOH 9:1) to give (RS)-4-(8-ethyl-naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole (38 mg) as light yellow gum. MS (ISP): 239.3 ((M+H)+).

Aufarbeitung

  1. concentrationconcentrated
  2. customThe crude product was purified by column chromatography (silica gel; eluent: CH2Cl2→CH2Cl2/MeOH 9:1)

Quellen und Nachweise

ORD-Eintrag
ord-dbb51d7f49384948ad7b6168a2413755
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07812047B2

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