Benzyl chloroformate → Benzyl 2-(2-tert-butylphenoxy)pyridin-3-ylcarbamate

HRID 1160234Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1160234
[C:1]([C:5]1[CH:20]=[CH:19][CH:18]=[CH:17][C:6]=1[O:7][C:8]1[C:13]([N:14]=C=O)=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:3])[CH3:2].Cl[C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23].CCN(C(C)C)C(C)C.[Cl-].[NH4+]>ClCCl>[C:1]([C:5]1[CH:20]=[CH:19][CH:18]=[CH:17][C:6]=1[O:7][C:8]1[C:13]([NH:14][C:22](=[O:23])[O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:12][CH:11]=[CH:10][N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

6

Edukt 4

HCID 10387Benzyl chloroformateHCID 25517Ammonium ChlorideHCID 81531DiisopropylethylamineHCID 574233152-(2-tert-Butylphenoxy)-3-isocyanatopyridine

Produkt 1

HCID 67026951Benzyl 2-(2-tert-butylphenoxy)pyridin-3-ylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 2-(2-tert-butylphenoxy)pyridin-3-amine (1a) (880 mg, 3.6 mmol), benzyl chloroformate (575 uL, 4.0 mmol) and Hunig's base (935 uL, 5.4 mmol) in dichloromethane (9.0 mL) was stirred at rt for 16 h. Saturated ammonium chloride was added and the separated aqueous layer was extracted with dichloromethane (3×15 mL). The combined organic layers were dried (anh. Magnesium sulfate), filtered and evaporated to yield a residue which was purified by reverse phase preparative HPLC. LC-MS m/z 377.1 [M+H]+.

Aufarbeitung

  1. extractionthe separated aqueous layer was extracted with dichloromethane (3×15 mL)
  2. dry with materialThe combined organic layers were dried (anh. Magnesium sulfate)
  3. filtrationfiltered
  4. customevaporated
  5. customto yield a residue which
  6. customwas purified by reverse phase preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-b65b071451824639b459b2397eda3b84
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07816382B2

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