Methanol → (S)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 1161197Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1161197
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14])([O-])=O.CO>ClCCl.[Pd]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 59515862(S)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

Produkt 1

HCID 59515789(S)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (S)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (1.3 g, 0.0050 mol) in methanol (40 mL, 1 mol) and dichloromethane (5 mL) was added palladium on charcoal (0.2 g, 0.001 mol) and stirred under hydrogen (1 atm) for 2 h. The reaction mixture was filtered over celite and the filtrate removed under reduced pressure to yield the pure product as an off white solid. MS m/z=232.5 (M+H).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered over celite
  2. customthe filtrate removed under reduced pressure
  3. customto yield the pure product as an off white solid

Quellen und Nachweise

ORD-Eintrag
ord-852084b2deca4b4cbab6be8f6936d647
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07816371B2

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