Methanol → (S)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 1161200Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1161200
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14])([O-])=O.CO>[Pd].ClCCl>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 59515862(S)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

Produkt 1

HCID 59515789(S)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A round bottom flask was charged with (S)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (1.3 g, 0.0050 mol),methanol (40 mL, 1 mol), dichloromethane (5 mL) and palladium on charcoal (0.2 g, 0.001 mol) were added and the mixture was stirred under hydrogen (1 atm) for 2 h. The reaction mixture was filtered over celite and the solvent removed under reduced pressure to yield the pure product as an off white solid. MS m/z=232.5 (M+H).

Aufarbeitung

  1. additionwere added
  2. filtrationThe reaction mixture was filtered over celite
  3. customthe solvent removed under reduced pressure
  4. customto yield the pure product as an off white solid

Quellen und Nachweise

ORD-Eintrag
ord-a453a90276da4f6cb8b83da4d55dfabe
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07816371B2

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