Methanol → (R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 1161203Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1161203
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14])([O-])=O.CO>[Pd].C(OC(=O)C)C>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]([C@H:15]([CH3:19])[C:16]([NH2:18])=[O:17])[C:9]2=[O:14]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 59515648(R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

Produkt 1

HCID 59515719(R)-2-(5-Amino-1-oxoisoquinolin-2(1H)-yl)propanamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A round bottom flask was charged with (R)-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide (5.0 g, 0.018 mol), palladium on charcoal (10%) (0.3 g, 0.003 mol) and methanol (200 mL, 5 mol) and ethylacetate (80 mL). The reaction mixture was stirred under hydrogen (1 atm) at room temperature for 40 minutes. The mixture was filtered over celite, the solvent was removed to yield the product as a light yellow solid. MS m/z=232.3 (M+H).

Aufarbeitung

  1. filtrationThe mixture was filtered over celite
  2. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-64195eda6fb0403d95b6686d34fb1398
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07816371B2

Notizen zur Reaktion

Wird geladen…