Dimethylformamide → Bicyclo[2.2.1]heptane-7-carbaldehyde

Temperatur

2.5 °C

15.9 g (81 mmol) of 7-Bromo-bicyclo[2.2.1]heptane were added dropwise to 2 g magnesium (81 mmol) in 25 ml of diethyl ether and refluxed for 2.5 h. The mixture was cooled to 0-5° C. and 6.3 ml (81 mmol) of DMF were added dropwise. The mixture was then refluxed for 2 h, cooled to room temperature and the white solid filtered off and washed with ether. The filtrate was reduced and 4.87 g of a white solid were obtained. The intermediate was used without further characterization.

1. temperaturerefluxed for 2.5 h
2. temperatureThe mixture was then refluxed for 2 h
3. temperaturecooled to room temperature
4. filtrationthe white solid filtered off
5. washwashed with ether

ORD-Eintrag

ord-3677f50506fc4935bf76f6977304ac04

Quelldatensatz

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07816540B2