HCID 59519105, Verbindung → 2-amino-N-(isopropylcarbamoylmethyl)-5-(4-methylperhydro-1,4-diazepin-1-yl)benzamide
Reaktionsgleichung
[CH:1]([NH:4][C:5]([CH2:7][NH:8][C:9](=[O:27])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:22][CH2:21][CH2:20][N:19]([CH3:23])[CH2:18][CH2:17]2)[CH:13]=[CH:12][C:11]=1[N+:24]([O-])=O)=[O:6])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:24][C:11]1[CH:12]=[CH:13][C:14]([N:16]2[CH2:22][CH2:21][CH2:20][N:19]([CH3:23])[CH2:18][CH2:17]2)=[CH:15][C:10]=1[C:9]([NH:8][CH2:7][C:5](=[O:6])[NH:4][CH:1]([CH3:3])[CH3:2])=[O:27]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A mixture of N-(isopropylcarbamoylmethyl)-5-(4-methylperhydro-1,4-diazepin-1-yl)-2-nitrobenzamide (510 mg, 1.4 mmol) and 10% Pd/C (60 mg) in MeOH (30 mL) was shaken under 50 psi H2 (g) in a Parr shaker for 5 h. The mixture was filtered through a pad of celite and the solvent removed in vacuo to afford 2-amino-N-(isopropylcarbamoylmethyl)-5-(4-methylperhydro-1,4-diazepin-1-yl)benzamide (INTERMEDIATE V.1) (470 mg, 1.4 mmol, 100%) as a brownish-green glass.