Ethanol → 4-(5-Amino-1-benzofuran-7-yl)pyridine

HRID 1161984Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1161984
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:7]2[O:11][CH:10]=[CH:9][C:8]=2[CH:12]=1)([O-])=O.C(O)C.O.NN>O1CCOCC1.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:7]2[O:11][CH:10]=[CH:9][C:8]=2[CH:12]=1

Komponenten

6

Edukt 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 66893958HCID 66893958, Verbindung2×

Produkt 1

HCID 668930874-(5-Amino-1-benzofuran-7-yl)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4-(5-Nitro-1-benzofuran-7-yl)pyridine (125 mg, 0.520 mmol; Intermediate 11) was dissolved in 1,4-dioxane (15 mL). After addition of ethanol (20 mL), Raney-nickel (slurry in ethanol; 2 mL) and hydrazine hydrate (4 mL) were added and the mixture was left stirring at room temperature overnight. The product was used directly in the subsequent reaction after filtration through Celite and evaporation of solvent.

Aufarbeitung

  1. additionwere added
  2. waitthe mixture was left
  3. customThe product was used directly in the subsequent reaction
  4. filtrationafter filtration
  5. customthrough Celite and evaporation of solvent

Quellen und Nachweise

ORD-Eintrag
ord-f1e37edef826442c9d9c704dbfd9df1c
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820675B2

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