Ethanol → N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine

HRID 1162001Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1162001
[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[O:17][CH:16]=[CH:15][C:14]=3[CH:13]=[C:12]([N+:19]([O-])=O)[CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(O)C.O.NN>C1COCC1.[Ni]>[N:1]1([CH2:7][CH2:8][NH:9][C:10]2[C:18]3[O:17][CH:16]=[CH:15][C:14]=3[CH:13]=[C:12]([NH2:19])[CH:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

6

Edukt 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 66893941HCID 66893941, Verbindung2×

Produkt 1

HCID 86058078N7-(2-Morpholin-4-ylethyl)-1-benzofuran-5,7-diamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

(2-Morpholin-4-ylethyl)(5-nitro-1-benzofuran-7-yl)amine (450 mg, 1.545 mmol; Intermediate 27) was dissolved in THF (5 mL). After addition of ethanol (100 mL), Raney-nickel (cat.) and hydrazine hydrate (2 mL), the mixture was left stirring at room temperature for 2 h. The product was used directly in the subsequent reaction after filtration through Celite and evaporation of solvent.

Aufarbeitung

  1. waitthe mixture was left
  2. customThe product was used directly in the subsequent reaction
  3. filtrationafter filtration
  4. customthrough Celite and evaporation of solvent

Quellen und Nachweise

ORD-Eintrag
ord-0f165c00b7cd496896c1e4dd1ff174f4
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820675B2

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