Oxalyl chloride → 4-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride

HRID 1162602Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1162602
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([C:15]([OH:17])=O)[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:21])=O>C(Cl)(Cl)Cl>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([C:15]([Cl:21])=[O:17])[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 207501802-Thiazolecarboxylic acid, 4-[4-(1-methylethyl)phenyl]-

Produkt 1

HCID 860798104-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

4-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride was prepared by refluxing a mixture of 4-(4-Isopropyl-phenyl)-thiazole-2-carboxylic acid (50 mg) and oxalyl chloride (300 μl) in chloroform (5 mL). After 3 h, the volatiles were evaporated and the residue was dried under high vacuum to provide the acid chloride (50 mg).

Aufarbeitung

  1. temperatureby refluxing
  2. customthe volatiles were evaporated
  3. customthe residue was dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-52b0ee15dd494030b44d3c5b9a598395
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820704B2

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