Methanesulfonyl chloride → HCID 58748264, Verbindung
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([NH:13][C:14]([C:16]2[S:17][C:18]([Cl:21])=[CH:19][CH:20]=2)=[O:15])[C@@H:10]([NH2:22])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:23][S:24](Cl)(=[O:26])=[O:25]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH:10]([NH:22][S:24]([CH3:23])(=[O:26])=[O:25])[C@@H:11]([NH:13][C:14]([C:16]2[S:17][C:18]([Cl:21])=[CH:19][CH:20]=2)=[O:15])[CH2:12]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]Komponenten
3
Versuchsvorschrift
35.3 In analogy to example 20.2 (S)-3-amino-4-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester was reacted with methane sulfonylchloride to give (S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methanesulfonylamino-pyrrolidine-1-carboxylic acid tert-butyl ester. White solid. MS 424.0 ([M+H]+)
Quellen und Nachweise
- ORD-Eintrag
- ord-28b434c8065e4b00a1d5ac67748caefb
- Quelldatensatz
- uspto-grants-2010_10
- Patentnummer