Methyl 1-benzyl-4-cyclopropylpyrrolidine-3-carboxylate → HCID 68646753, Verbindung

HRID 1162724Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1162724
[CH3:1][O:2][C:3]([CH:5]1[CH:9]([CH:10]2[CH2:12][CH2:11]2)[CH2:8][N:7](CC2C=CC=CC=2)[CH2:6]1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH:9]([CH:10]2[CH2:12][CH2:11]2)[CH2:8][NH:7][CH2:6]1)=[O:4]

Komponenten

4

Edukt 1

HCID 68647670Methyl 1-benzyl-4-cyclopropylpyrrolidine-3-carboxylate

Produkt 1

HCID 68646753HCID 68646753, VerbindungAusbeute 85,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

101.2 To a stirred solution of 1.13 g (3RS,4RS)-1-benzyl-4-cyclopropyl-pyrrolidine-3-carboxylic acid methyl ester at r.t. in 10 ml methanol under an argon atmosphere was added 113 mg 10% Pd/C. The mixture was then stirred at r.t. under a hydrogen atmosphere overnight. The catalyst was filtered off and rinsed with methanol. The filtrate was concentrated to leave 630 mg (3RS,4RS)-4-cyclopropyl-pyrrolidine-3-carboxylic acid methyl ester as a light yellow oil. MS170.3 ([M+H]+)

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washrinsed with methanol
  3. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-326128ba9de0496c9db24ebe38b2f4e5
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820699B2

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