4-Methoxyphenol → 4-Methoxyphenol

After 4-methoxyphenol (300 mg, 2.41 mmol), triphenylphosphine (761 mg, 2.89 mmol), (2R,4R)-2,4-pentanediol (302 mg, 2.89 mmol), and THF (12 mL) were added to a 50 ml flask, azodicarboxylic acid bis(2-methoxyethyl) ester (680 mg, 2.89 mmol) dissolved in THF (6 ml) was added dropwise thereto at 20° C., and the reaction was allowed to proceed for 14 hours. Water (0.5 ml) was added, and concentration was carried out. Then, water (10 ml) was added to the solution, and extraction was carried out using diethyl ether (10 mL,×2). Then, the organic layer was washed with water (10 ml) and saturated salt water (10 ml), and dehumidified with anhydrous magnesium sulfate. Subsequently, a crude product obtained by concentration was purified by column chromatography (silica gel, 30% ethyl acetate-hexane solution) to give (4S,2R)-4-(4-methoxyphenoxy)pentane-2-ol as a colorless oily substance (418 mg, yield: 82%/4-methoxyphenol).

1. additionwas added dropwise
2. customat 20° C.
3. concentrationconcentration
4. additionThen, water (10 ml) was added to the solution, and extraction
5. washThen, the organic layer was washed with water (10 ml) and saturated salt water (10 ml)
6. customSubsequently, a crude product obtained by concentration
7. customwas purified by column chromatography (silica gel, 30% ethyl acetate-hexane solution)

ORD-Eintrag

ord-e2e781d4303b495287866571ae9eea62

Quelldatensatz

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07820802B2