Hydrochloric Acid → Sodium 4-hydroxyphenylglycolate

HRID 1164268

Reaktionsgleichung

Reaktionsgleichung von HRID 1164268
[OH-].[Na+:2].[C:3]1([OH:9])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:10]([OH:14])(=[O:13])[CH:11]=[O:12].Cl>O>[OH:9][C:3]1[CH:8]=[CH:7][C:6]([CH:11]([OH:12])[C:10]([O-:14])=[O:13])=[CH:5][CH:4]=1.[Na+:2]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 760Glyoxylic AcidHCID 996PhenolHCID 14798Sodium Hydroxide

Produkt 1

HCID 23663713Sodium 4-hydroxyphenylglycolate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Sodium hydroxide solution (50% w/w, ca 650 ml) was added dropwise over about one hour to a stirred mixture of phenol (1.098 kg), aqueous glyoxylic acid (50% w/w solution, 720 ml) and water (3 l) at 15° C. until a pH of 10.5 had been reached. The reaction mixture was then stirred and tested at 35° C. for 3 hours. The solution was adjusted to pH7 with concentrated hydrochloric acid and extracted at 35° C. with methyl isobutyl ketone to remove excess phenol. The aqueous solution was adjusted to pH2 with concentrated hydrochloric acid and continuously extracted in a counter-current extractor with ethyl acetate at an organic to aqueous flow rate of 1 to 1.

Aufarbeitung

  1. extractionextracted at 35° C. with methyl isobutyl ketone
  2. customto remove excess phenol
  3. extractioncontinuously extracted in a counter-current extractor with ethyl acetate at an organic to aqueous flow rate of 1 to 1

Quellen und Nachweise

ORD-Eintrag
ord-fe69483683fc42e5807e4062cdeb1b0b
Quelldatensatz
uspto-grants-1983_01
Patentnummer
US04368334

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