Water → 2,3,5-Trimethylanisole

HRID 1164287

Reaktionsgleichung

Reaktionsgleichung von HRID 1164287
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH3:9])=[CH:4][C:3]=1[OH:10].[CH3:11]I.[H-].[Na+].O>CS(C)=O>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH3:9])=[CH:4][C:3]=1[O:10][CH3:11]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 127692,3,5-TrimethylphenolHCID 24758Sodium hydride

Produkt 1

HCID 885552,3,5-Trimethylanisole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

In 100 ml of DMSO were dissolved 10 g of 2,3,5-trimethylphenol and 10.4 ml of methyl iodide. Under ice-cooling, 5.6 g of 60% sodium hydride in oil was added, and the mixture was stirred at room temperature for 10 hours. After addition of water, the extraction with ether was carried out. The ether layer was washed with water and dried over anhydrous sodium sulfate. Removal of the solvent by distillation leaves the oily substance.

Aufarbeitung

  1. temperatureUnder ice-cooling
  2. extractionthe extraction with ether
  3. washThe ether layer was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customRemoval of the solvent
  6. distillationby distillation
  7. customleaves the oily substance

Quellen und Nachweise

ORD-Eintrag
ord-aede883a8b074a459804852b1da692c8
Quelldatensatz
uspto-grants-1983_01
Patentnummer
US04368150

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