Hydrazine hydrate (1:1) → 6,7-Dimethoxy-1,2-dihydrophthalazin-1-one

HRID 1164508

Reaktionsgleichung

Reaktionsgleichung von HRID 1164508
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:14]=O)[C:6](=[CH:10][C:11]=1[O:12][CH3:13])[C:7](O)=[O:8].O.[NH2:17][NH2:18]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:6](=[CH:10][C:11]=1[O:12][CH3:13])[C:7](=[O:8])[NH:18][N:17]=[CH:14]2

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 71762072-Formyl-4,5-dimethoxybenzoic acid

Produkt 1

HCID 122985456,7-Dimethoxy-1,2-dihydrophthalazin-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4,5-Dimethoxyphthalaldehydic acid (10 g.) and hydrazine hydrate (2.4 ml.) in ethanol (150 ml.) were heated under reflux for 20 hours during which time a white crystalline solid formed. The mixture was cooled in an ice bath, filtered and the resulting product dried to give crude 6,7-dimethoxyphthalazin-1-one (7 g.). A sample was crystallized from water yielding colorless needles, m.p. 254°-256° C.

Aufarbeitung

  1. temperatureunder reflux for 20 hours during which time a white crystalline solid
  2. customformed
  3. temperatureThe mixture was cooled in an ice bath
  4. filtrationfiltered
  5. customthe resulting product dried

Quellen und Nachweise

ORD-Eintrag
ord-153785bad39141c4860e60f40756846b
Quelldatensatz
uspto-grants-1983_01
Patentnummer
US04370328

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