Benzoyl Peroxide → 3-(Bromomethyl)-1,2,4,5-tetrafluorobenzene

A mixture of 2,3,5,6-tetrafluorotoluene (1.7 g), N-bromosuccinimide (1.9 g), dry carbon tetrachloride (10 ml) and benzoyl peroxide (0.01 g) was heated at the reflux temperature for 20 hours, cooled to the ambient temperature (ca.25° C.) filtered and the filtrate diluted with diethyl ether. The ethereal solution was washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvents to yield 2,3,5,6-tetrafluorobenzyl bromide as a mobile colourless oil.

1. temperaturewas heated at the reflux temperature for 20 hours
2. filtrationfiltered
3. additionthe filtrate diluted with diethyl ether
4. washThe ethereal solution was washed with water
5. dry with materialdried over anhydrous magnesium sulphate
6. concentrationconcentrated by evaporation of the solvents

ORD-Eintrag

ord-8fc3a240a9194d0dba4b7b2cf1fd0e24

Quelldatensatz

uspto-grants-1983_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04370346