Ammonia → 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 1164802

Reaktionsgleichung

Reaktionsgleichung von HRID 1164802
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:10][CH2:11][C:12](=[O:15])[NH:13][N:14]=2)=[CH:5][CH:4]=1.O1[CH:21]=[CH:20][C:19](=[O:22])[CH:18]=[CH:17]1.N>O>[O:22]=[C:19]1[CH:20]=[CH:21][N:2]([C:3]2[CH:8]=[CH:7][C:6]([C:9]3[CH2:10][CH2:11][C:12](=[O:15])[NH:13][N:14]=3)=[CH:5][CH:4]=2)[CH:17]=[CH:18]1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 79684H-pyran-4-oneHCID 128050056-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride

Produkt 1

HCID 197942256-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A stirred mixture of 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride (1.5 g), 4H-pyran-4-one (0.7 g), and water (20 ml), was heated under reflux for 41/2 hours. The resultant solid was dissolved in the minimum of hot water and the solution was neutralised with ammonia to give the crude product. Recrystallisation from water gave the title compound, 0.73 g, m.p. 270°-272° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 41/2 hours
  3. customto give the crude product
  4. customRecrystallisation from water

Quellen und Nachweise

ORD-Eintrag
ord-8fff56dbcde544d9a17b631b62886d5f
Quelldatensatz
uspto-grants-1990_03
Patentnummer
US04906628

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