Methyl Ethyl Ketone → Androst-4,7-diene-3,17-dione

HRID 1165509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1165509
[CH3:1][C@:2]12[CH2:19][CH2:18][C@H:17]3[C:7](=[CH:8][CH:9]=[C:10]4[C@:15]3([CH3:16])[CH2:14][CH2:13][C@H:12]([OH:20])[CH2:11]4)[C@@H:6]1[CH2:5][CH2:4][C@@H:3]2[OH:21].CC(=O)CC.CC(C)[O-].[Al+3].CC(C)[O-].CC(C)[O-]>C1(C)C=CC=CC=1>[CH3:1][C@:2]12[CH2:19][CH2:18][C@H:17]3[C:7](=[CH:8][CH2:9][C:10]4[C@:15]3([CH3:16])[CH2:14][CH2:13][C:12](=[O:20])[CH:11]=4)[C@@H:6]1[CH2:5][CH2:4][C:3]2=[O:21]

Komponenten

5

Edukt 3

HCID 6569Methyl Ethyl KetoneHCID 11143Aluminum isopropoxideHCID 9817420Androsta-5,7-diene-3b,17b-diol

Produkt 1

HCID 14369573Androst-4,7-diene-3,17-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of androst-5,7-diene-3β,17β-diol (2.9 g, 10 mmol) in 150 ml toluene is azeotropically dried for one hour. Butanone (15 ml) is added followed by aluminum isopropoxide (1.7 g,8 mmol) and the mixture is heated at reflux for 2.5 hours. The solution is then concentrated to a volume of 25 ml, diluted with trichloromethane, and washed with 5% hydrochloric acid, aqueous sodium bicarbonate, and brine. Concentration and chromatography affords androst-4,7-diene-3,17-dione.

Aufarbeitung

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 2.5 hours
  3. concentrationThe solution is then concentrated to a volume of 25 ml
  4. additiondiluted with trichloromethane
  5. washwashed with 5% hydrochloric acid, aqueous sodium bicarbonate, and brine
  6. concentrationConcentration and chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3ab383a8e0344875ba135a2c5ef4f68c
Quelldatensatz
uspto-grants-1990_03
Patentnummer
US04910226

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