Acetic Anhydride → 2-(1,3-Benzodioxol-5-yl)ethyl acetate
Reaktionsgleichung
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH:10](O)[CH3:11])=[CH:4][C:3]=2[O:2]1.[C:13]([O:16]C(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([O:16][CH2:11][CH2:10][C:5]1[CH:6]=[CH:7][C:8]2[O:9][CH2:1][O:2][C:3]=2[CH:4]=1)(=[O:15])[CH3:14]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
To a stirred solution of 2-(3,4-methylenedioxy)phenyl-1-ethanol (1.68 g, 10 mmol) in dry pyridine was added acetic anhydride and the resultant reaction mixture was stirred at 80° C. for 1 h. The reaction mixture was poured into ice-water and was extracted with ether (2×75 ml). The combined ether extract was washed with water (2×50 ml), 5% Hcl (2×50 ml) and then with 5% NaHCO3 (2×50 ml). The organic layer was dried over magnesium sulfate and the solvent was removed under reduced pressure to give 1-acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane as a solid (1.7 g, 81% yield).
Aufarbeitung
- customthe resultant reaction mixture
- extractionwas extracted with ether (2×75 ml)
- extractionThe combined ether extract
- washwas washed with water (2×50 ml), 5% Hcl (2×50 ml)
- dry with materialThe organic layer was dried over magnesium sulfate
- customthe solvent was removed under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-e4c0982f23254fa482ad62c204878a55
- Quelldatensatz
- uspto-grants-2003_09
- Patentnummer
- US06613804B2
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